Serre J L
Université de Versailles/Saint-Quentin-en-Yvelines, Laboratoire de génétique épidémiologique, unité U 155 de l'INSERM.
Contracept Fertil Sex. 1993 May;21(5):386-7.
The absolute frequency of offsprings with diseases due to new autosomal dominant mutations in sperm, is growing according to paternal age. But a careful review of literature upon this topic as well as the actual estimation of the increased number of affected offspring within the limited number of newborns issued from semen donors, lead to moderate the conservative conclusions of american authors favoring a severe limitation of the upper limit of age for semen donors.
由于精子中出现新的常染色体显性突变而导致后代患疾病的绝对频率,会随着父亲年龄的增长而增加。但是,对该主题的文献进行仔细回顾,以及对精液捐献者所生育的有限数量新生儿中受影响后代数量增加情况的实际估计,使得人们对美国作者支持严格限制精液捐献者年龄上限的保守结论有所缓和。