D'Avanzo B, Santoro L, La Vecchia C, Maggioni A, Nobili A, Iacuitti G, Franceschi S
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Ann Epidemiol. 1993 Nov;3(6):645-51.
The relationship between physical activity and acute myocardial infarction (AMI) was examined in a case-control study conducted in Italy in 1988 to 1989 within the framework of the GISSI-2 trial of streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 916 case patients admitted to coronary care units from various Italian regions for AMI were interviewed. Control subjects were 1106 patients admitted to the same network of hospitals for a broad spectrum of acute diseases not related to known or potential risk factors for myocardial infarction. Among various types of physical activity (occupational activity, walking, stair climbing, and sport and leisure-time physical activity), occupational physical exercise emerged as the most protective. Multivariate odds ratios (ORs) were 1.4 (95% confidence interval (CI), 1.0 to 2.0) and 1.6 (95% CI, 1.2 to 2.1) for the two lowest levels of occupational physical activity. The trends of increasing risk with decreasing activity were consistent, although less strong, when other types of activity were considered. The protection conveyed by occupational physical activity was similar across various strata of sex, age, education, smoking habits, and diabetes, and was not explained by serum cholesterol, body weight, or hypertension. This study therefore confirms that low physical activity is an indicator of subsequent risk of AMI.
在1988年至1989年于意大利开展的一项病例对照研究中，在急性心肌梗死（AMI）治疗中链激酶与阿替普酶以及肝素与无肝素对比的GISSI - 2试验框架内，对体力活动与急性心肌梗死之间的关系进行了研究。总共对来自意大利不同地区因急性心肌梗死入住冠心病监护病房的916例病例患者进行了访谈。对照对象为1106例因各种与已知或潜在心肌梗死危险因素无关的急性疾病入住同一医院网络的患者。在各类体力活动（职业活动、步行、爬楼梯以及运动和休闲时间的体力活动）中，职业体育锻炼显示出最强的保护作用。职业体力活动水平最低的两个等级的多变量优势比（OR）分别为1.4（95%置信区间（CI），1.0至2.0）和1.6（95%CI，1.2至2.1）。在考虑其他类型活动时，活动量减少风险增加的趋势是一致的，尽管不那么明显。职业体力活动所带来的保护作用在性别、年龄、教育程度、吸烟习惯和糖尿病等不同分层中相似，且无法用血清胆固醇、体重或高血压来解释。因此，本研究证实低体力活动是随后发生急性心肌梗死风险的一个指标。
