印记与遗传早现。它们与精神分裂症的遗传学研究相关吗？

Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia?

作者信息

Asherson P, Walsh C, Williams J, Sargeant M, Taylor C, Clements A, Gill M, Owen M, McGuffin P

机构信息

Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff.

出版信息

Br J Psychiatry. 1994 May;164(5):619-24. doi: 10.1192/bjp.164.5.619.

DOI:10.1192/bjp.164.5.619

PMID:7921711

Abstract

Among 29 multiply affected pedigrees, age of onset among parents and offspring was examined for evidence of both anticipation and genomic imprinting. The results do not suggest that either mechanism is operating in schizophrenia, but only very large effects can be confidently excluded.

摘要

在29个多例受累的家系中，研究了父母和后代的发病年龄，以寻找遗传早现和基因组印记的证据。结果并不表明这两种机制在精神分裂症中起作用，但只有非常大的影响才能被确定排除。