RATANENDRA KUMAR, MBBS., DPM., Resident, Department of Psychiatry, C.I.P., Ranchi.
Indian J Psychiatry. 2000 Apr;42(2):167-71.
With recent advances in molecular genetics, a new mechanism proposed for the inheritance of Bipolar Disorder is Genomic Imprinting or Parent of Origin Affect. In this study of 79 consecutive first episode manic patients, predominantly male, we failed to establish the phenomenon of imprinting. With other proposed non-Mendelian patterns of inheritance, it may be that bipolar disorder is genetically heterogenous.
随着分子遗传学的最新进展，提出了一种新的双相情感障碍遗传机制，即基因组印记或亲代来源影响。在这项对 79 例首发躁狂患者的连续研究中，主要为男性，我们未能确定印记现象。对于其他提出的非孟德尔遗传模式，双相情感障碍可能具有遗传异质性。
