MacSweeney S T, Powell J T, Greenhalgh R M
Department of Surgery, Charing Cross and Westminster Hospital Medical School, London, UK.
Br J Surg. 1994 Jul;81(7):935-41. doi: 10.1002/bjs.1800810704.
The pathogenesis of abdominal aortic aneurysm involves many factors acting over time. However, destruction of elastin in the aortic wall is a key event that shifts the load produced by blood pressure on to collagen. This is exacerbated in the presence of hypertension. Smoking and age are further important factors, as is the site; elastic lamellae are relatively less common in the abdominal aorta. Once the shielding effect of elastin is lost, further dilatation and rupture of the aorta depend on the physical properties of the collagen present.
腹主动脉瘤的发病机制涉及多种因素长期作用。然而，主动脉壁中弹性蛋白的破坏是一个关键事件，它将血压产生的负荷转移到胶原蛋白上。在高血压情况下，这种情况会加剧。吸烟、年龄以及部位也是重要因素；弹性层在腹主动脉中相对较少见。一旦弹性蛋白的保护作用丧失，主动脉的进一步扩张和破裂就取决于所存在胶原蛋白的物理特性。
