Elliott W J
Department of Preventive Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Curr Opin Nephrol Hypertens. 1994 May;3(3):271-8.
Results of treatment in clinical practice and in randomized trials are usually improved when patients actually take their medications as prescribed. This is particularly important in chronic diseases such as hypertension and renal impairment, in which specific, recurrent, troubling symptoms are unlikely to be remedied with therapy. Compliance with medication often parallels appointment adherence, which also improves long-term outcomes. Factors that improve compliance include culturally sensitive patient education and attitude about the disease undergoing treatment; patient-specific reminders (eg, computed medication reminders and charts); medical regimens that minimize the frequency, inconvenience, and number of pills taken; and positive physician attitude regarding therapy.
在临床实践和随机试验中，如果患者确实按医嘱服药，治疗效果通常会得到改善。这在高血压和肾功能损害等慢性疾病中尤为重要，因为这些疾病不太可能通过治疗消除特定的、反复出现的、令人困扰的症状。药物依从性通常与预约依从性并行，这也能改善长期治疗效果。提高依从性的因素包括对患者具有文化敏感性的教育以及对所治疗疾病的态度；针对患者的提醒（如计算机化药物提醒和图表）；尽量减少服药频率、不便之处和药片数量的治疗方案；以及医生对治疗的积极态度。
