Eisen S A, Miller D K, Woodward R S, Spitznagel E, Przybeck T R
St Louis Veterans Affairs Medical Center, MO 63106.
Arch Intern Med. 1990 Sep;150(9):1881-4.
The objective of this study was to determine the relationship between prescribed daily dose frequency and patient medication compliance. The medication compliance of 105 patients receiving antihypertensive medications was monitored by analyzing data obtained from special pill containers that electronically record the date and time of medication removal. Inaccurate compliance estimates derived using the simple pill count method were thereby avoided. Compliance was defined as the percent of days during which the prescribed number of doses were removed. Compliance improved from 59.0% on a three-time daily regimen to 83.6% on a once-daily regimen. Thus, compliance improves dramatically as prescribed dose frequency decreases. Probably the single most important action that health care providers can take to improve compliance is to select medications that permit the lowest daily prescribed dose frequency.
本研究的目的是确定每日规定剂量频率与患者用药依从性之间的关系。通过分析从特殊药盒获取的数据来监测105名接受抗高血压药物治疗患者的用药依从性，这些药盒能电子记录取出药物的日期和时间。从而避免了使用简单的药片计数法得出不准确的依从性估计值。依从性定义为取出规定剂量的天数百分比。依从性从每日三次服药方案的59.0%提高到每日一次服药方案的83.6%。因此，随着规定剂量频率的降低，依从性显著提高。医疗保健提供者为提高依从性可以采取的可能是最重要的单一行动，就是选择允许最低每日规定剂量频率的药物。
