DeBiasse M A, Wilmore D W
Department of Nutrition, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
New Horiz. 1994 May;2(2):122-30.
Nutritional support of the seriously ill patient has evolved with time and reflects new developments in the field of critical care. Current information suggests that optimal nutritional support can be provided by supplying at least 80% of energy requirements with at least 70% of the energy given as carbohydrate and the remaining 30% or less administered as fat (with > or = 3% of energy requirements as essential fatty acids). The caloric load may be reduced to 50% of requirements if growth factors (e.g., growth hormone) are utilized and the patient has adequate fat stores. Protein should be given as 1.5 g/kg/day; more catabolic patients, such as patients with burn injury, should receive 2 g/kg/day. All protein or amino acid feeding should include glutamine. There is an increased need for vitamins (especially A, C, and E) and minerals (zinc, selenium, and magnesium). The preferred route of feeding should be enteral, followed by enteral plus supplemental parenteral nutrition. If the gastrointestinal tract cannot be used, parenteral nutrition should be given. Nutrients should be administered early in the catabolic course, especially glucose, sodium, potassium, vitamins, and minerals. Over time (approximately 7 days) amino acids should be added and approximately 50% of caloric support should be provided. Finally, full nutritional support should be provided (by 7 to 10 days) if the catabolic course is expected to continue.
重症患者的营养支持随着时间不断发展,反映了重症监护领域的新进展。目前的信息表明,通过提供至少80%的能量需求,其中至少70%的能量以碳水化合物形式提供,其余30%或更少以脂肪形式提供(必需脂肪酸占能量需求的≥3%),可以实现最佳营养支持。如果使用生长因子(如生长激素)且患者有足够的脂肪储备,热量负荷可降至需求的50%。蛋白质应按1.5 g/kg/天给予;分解代谢更强的患者,如烧伤患者,应接受2 g/kg/天。所有蛋白质或氨基酸喂养都应包含谷氨酰胺。对维生素(尤其是A、C和E)和矿物质(锌、硒和镁)的需求增加。首选的喂养途径应为肠内营养,其次是肠内营养加补充性肠外营养。如果不能使用胃肠道,则应给予肠外营养。营养物质应在分解代谢过程早期给予,尤其是葡萄糖、钠、钾、维生素和矿物质。随着时间推移(约7天),应添加氨基酸,并提供约50%的热量支持。最后,如果预计分解代谢过程会持续,应(在7至10天内)提供全面的营养支持。