Roberts P R, Zaloga G P
Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1009.
New Horiz. 1994 May;2(2):237-43.
Evidence indicates that hydrolyzed protein fragments (i.e., peptides) cross the small intestine and reach peripheral tissue via the systemic circulation. Dietary peptides can have specific actions locally, on the gastrointestinal tract, or at more distant sites. These bioactive peptides can alter cellular metabolism and may act as vasoregulators, growth factors, releasing hormones, or neurotransmitters. The available nitrogen choices for enteral nutrition are free amino acids, peptides, or intact proteins. Current experimental evidence indicates that diets that possess the capability of producing luminal peptides are superior to diets lacking this capacity. The parent protein used for enteral nutrition generates specific peptides that can also dictate a variety of metabolic responses. The concept of dietary bioactive peptides offers an explanation for varying effects of diet on physiologic responses. These concepts have spurred research efforts into the possibility of enteral administration of biogenic amines.
有证据表明，水解蛋白片段（即肽）可穿过小肠，并通过体循环到达外周组织。膳食肽可在局部、胃肠道或更远的部位产生特定作用。这些生物活性肽可改变细胞代谢，并可能作为血管调节剂、生长因子、释放激素或神经递质发挥作用。肠内营养可选用的氮源有游离氨基酸、肽或完整蛋白质。目前的实验证据表明，能够产生肠腔肽的饮食优于缺乏这种能力的饮食。用于肠内营养的母体蛋白会产生特定的肽，这些肽也可决定多种代谢反应。膳食生物活性肽的概念为饮食对生理反应的不同影响提供了解释。这些概念激发了对肠内给予生物胺可能性的研究。
