Zdanowicz A, Jabłońska E, Pietruska Z, Bielecki M
Department of Obstetrics, Medical University Białystok.
Ann Med Univ Bialyst Pol. 1993;38(1):60-7.
The complement levels were determined in 54 parturient women with EPH gestosis, in 32 normal parturient women and in 24 normal non pregnant women. Complement components: C4, C3c, factor B /Bf/ and C1 inactivator /C1 INA/ were measured by radial immunodiffusion. Peripheral and retroplacental blood were examined. Concentrations of C4, C3c, Bf in peripheral blood of both groups of parturient women were significantly higher than in normal non pregnant women. Peripheral blood of parturient women with EPH gestosis contained significantly higher concentrations of C3c than in normal parturient women. Complement Bf levels of normal parturient women were lower in the retroplacental blood than in the peripheral. The levels of C4 were significantly decreased and C3c increased in the retroplacental blood of parturient women with EPH gestosis when results were compared with retroplacental blood of normal parturient women. Results of present study suggest that complement activation could contribute to the pathogenesis of EPH gestosis.
对54例患妊娠高血压综合征的产妇、32例正常产妇及24例正常未孕妇女测定了补体水平。补体成分：C4、C3c、B因子/Bf/及C1灭活剂/C1 INA/采用单向免疫扩散法测定。检查了外周血和胎盘后血。两组产妇外周血中C4、C3c、Bf的浓度均显著高于正常未孕妇女。患妊娠高血压综合征的产妇外周血中C3c的浓度显著高于正常产妇。正常产妇胎盘后血中补体Bf水平低于外周血。与正常产妇的胎盘后血相比，患妊娠高血压综合征的产妇胎盘后血中C4水平显著降低，C3c水平升高。本研究结果提示补体激活可能与妊娠高血压综合征的发病机制有关。
