Ardelt A A, Flaris N A, Roth K A
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Brain Res. 1994 Jun 6;647(2):340-4. doi: 10.1016/0006-8993(94)91333-1.
The neurotrophins (NGF, BDNF, NT-3, and NT-4) provide trophic support to subpopulations of neurons in the central and peripheral nervous systems. We examined organotypic slices of neonatal mouse striatum maintained in medium supplemented with neurotrophins or with CNTF to determine which of these factors influence the survivability of striatal neurons. Neuron counts at the end of the culture period revealed that NT-4 was the only factor that had a significant effect on neuronal survival, suggesting that NT-4 is a trophic factor for striatal neurons in organotypic slices.
神经营养因子（神经生长因子、脑源性神经营养因子、神经营养素-3和神经营养素-4）为中枢和外周神经系统中的神经元亚群提供营养支持。我们检测了在添加神经营养因子或睫状神经营养因子的培养基中培养的新生小鼠纹状体器官型切片，以确定这些因子中哪些会影响纹状体神经元的存活能力。培养期末的神经元计数显示，神经营养素-4是唯一对神经元存活有显著影响的因子，这表明神经营养素-4是器官型切片中纹状体神经元的一种营养因子。
