DiScenna P G, Ferchmin P A, Eterovic V A, Teyler T J
Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Brain Res. 1994 Jun 6;647(2):353-6. doi: 10.1016/0006-8993(94)91335-8.
The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and GABA-mediated monosynaptic population IPSPs. These effects contrast with its well-known potentiation of NMDA currents at lower concentrations. Our results raise the possibility that the large intracellular stores of spermine that are released after various neural insults could act as an endogenous neuroprotective mechanism by limiting excessive calcium entry.
在内源性多胺精胺对大鼠海马脑片CA1区的作用研究中，低毫摩尔浓度的精胺能快速且显著地抑制NMDA和K/AMPA介导的群体兴奋性突触后电位（EPSP）以及GABA介导的单突触群体抑制性突触后电位（IPSP）。这些作用与其在较低浓度下对NMDA电流的著名增强作用形成对比。我们的研究结果提示，在各种神经损伤后释放的大量细胞内精胺储存可能通过限制过多的钙内流而作为一种内源性神经保护机制。
