Herroelen L, De Backer J P, Wilczak N, Flamez A, Vauquelin G, De Keyser J
Department of Neurology, Academisch Ziekenhuis, Brussels, Belgium.
Brain Res. 1994 Jun 20;648(2):222-8. doi: 10.1016/0006-8993(94)91121-5.
The regional distribution of D3 dopamine receptors was studied in human brain by quantitative autoradiography with [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin ([3H]7-OH-DPAT). The highest densities were found in the ventral striatum/nucleus accumbens, followed by the remainder of the neostriatum, cerebral cortex, and cerebellar cortex. Moderate amounts were found in the substantia nigra. Low densities of D3 dopamine receptors were visualized in pituitary gland (posterior lobe > anterior lobe), amygdala, and hippocampus. The globus pallidus and thalamus contained lower densities. The distribution pattern is much more widespread as detected by in situ hybridisation histochemistry for D3 mRNA in human and in rat brain. Our data confirm a predilection of D3 receptors in brain areas involved in cognitive and emotional functions. The presence of D3 receptors in non-limbic parts of the neostriatum and substantia nigra suggests that they also play a role in the dopaminergic control of motor processes. Its precise function in cerebellum and pituitary gland is at present uncertain.
采用[3H]7-羟基-N,N-二正丙基-2-氨基四氢萘（[3H]7-OH-DPAT）通过定量放射自显影法研究了人脑D3多巴胺受体的区域分布。最高密度出现在腹侧纹状体/伏隔核，其次是新纹状体的其余部分、大脑皮层和小脑皮层。黑质中含量适中。在垂体（后叶>前叶）、杏仁核和海马体中可见低密度的D3多巴胺受体。苍白球和丘脑的密度较低。通过人及大鼠脑内D3 mRNA原位杂交组织化学检测到的分布模式更为广泛。我们的数据证实了D3受体在参与认知和情感功能的脑区中的偏好性。新纹状体和黑质非边缘部分存在D3受体，表明它们在多巴胺能对运动过程的控制中也发挥作用。其在小脑和垂体中的精确功能目前尚不确定。
