顺铂可阻断豚鼠耳蜗离体外毛细胞的电压依赖性钙电流。

Cisplatin blocks voltage-dependent calcium current in dissociated outer hair cells of guinea-pig cochlea.

作者信息

Yamamoto T, Kakehata S, Saito T, Saito H, Akaike N

机构信息

Department of physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.

出版信息

Brain Res. 1994 Jun 20;648(2):296-8. doi: 10.1016/0006-8993(94)91130-4.

DOI:10.1016/0006-8993(94)91130-4

PMID:7922544

Abstract

The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.

摘要

使用全细胞膜片钳技术研究了耳毒性分子顺铂（顺式二氨基二氯铂）对豚鼠耳蜗分离外毛细胞（OHC）中电压依赖性Ca2+通道的影响。顺铂对Ca2+通道具有拮抗作用，并以浓度依赖性方式可逆地抑制Ca2+电流。这些结果表明，顺铂的耳毒性机制之一涉及对OHC中Ca2+通道的抑制。