Cisplatin blocks voltage-dependent calcium current in dissociated outer hair cells of guinea-pig cochlea.
作者信息
Yamamoto T, Kakehata S, Saito T, Saito H, Akaike N
机构信息
Department of physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
出版信息
Brain Res. 1994 Jun 20;648(2):296-8. doi: 10.1016/0006-8993(94)91130-4.
PMID:7922544
Abstract
The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.
摘要
Zotero 插件