顺铂可阻断离体耳蜗外毛细胞的电压依赖性钙电流，但在体内无耳毒性。

Transplatin blocks voltage-dependent calcium current in isolated cochlear outer hair cells but is not ototoxic in vivo.

作者信息

Saito T, Yamamoto T, Zhang Z J, Yamada T, Manabe Y, Saito H

机构信息

Department of Otolaryngology, Fukai Medical School, Japan.

出版信息

Brain Res. 1995 Oct 30;697(1-2):276-9. doi: 10.1016/0006-8993(95)00998-6.

DOI:10.1016/0006-8993(95)00998-6

PMID:8593591

Abstract

The effects of cisplatin (cis-DDP) and transplatin (trans-DDP) on the voltage-dependent calcium current (ICa) of outer hair cells isolated from the guinea pig cochlea were compared using the whole-cell patch-clamp technique. Both cis-DDP and trans-DDP blocked ICa in a concentration-dependent manner. Trans-DDP did not show ototoxicity or nephrotoxicity in vivo. From these results, it was suggested that the effect of cis-DDP on ICa does not directly lead to cell death.

摘要

采用全细胞膜片钳技术比较了顺铂（cis-DDP）和反铂（trans-DDP）对从豚鼠耳蜗分离的外毛细胞电压依赖性钙电流（ICa）的影响。顺铂和反铂均以浓度依赖性方式阻断ICa。反铂在体内未表现出耳毒性或肾毒性。从这些结果推测，顺铂对ICa的作用并不直接导致细胞死亡。