Haran E F, Maretzek A F, Goldberg I, Horowitz A, Degani H
Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel.
Cancer Res. 1994 Nov 1;54(21):5511-4.
Magnetic resonance imaging at high spatial resolution and histochemical staining were applied to monitor the influence of tamoxifen versus estrogen on the growth, endothelial density, and extent of necrosis in tumors of MCF7 human breast cancer cells implanted in nude mice. Concomitantly with tamoxifen growth arrest, a highly significant decrease, by more than 2-fold, in the endothelial density of viable tumor regions had occurred, together with a significant increase in the extent of necrosis. The results suggest that the antiestrogenic activity of tamoxifen in breast cancer, which results in enhanced necrosis and tumor regression, is due to the inhibition of angiogenesis and of endothelial growth, thus reducing vascularization and impairing tumor perfusion.
应用高空间分辨率磁共振成像和组织化学染色来监测他莫昔芬与雌激素对植入裸鼠体内的MCF7人乳腺癌细胞肿瘤生长、内皮细胞密度和坏死程度的影响。伴随他莫昔芬导致的生长停滞，存活肿瘤区域的内皮细胞密度显著下降超过2倍，同时坏死程度显著增加。结果表明，他莫昔芬在乳腺癌中的抗雌激素活性导致坏死增强和肿瘤消退，这是由于抑制了血管生成和内皮生长，从而减少血管化并损害肿瘤灌注。
