Zhu G, Tao H, Huang Z
Shanghai Institute of Biological Products.
Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Apr;15(2):80-2.
A procedure of keeping Danish BCG strain 2 is reported. The strain is cultivated in Bile potato Medium and Suton Potato Medium alternatively with incubation periods of two weeks. Lyophilized vaccine produced by using seeds derived from this strain gives better immunogenicity and lower side reaction to new-born babies and has better thermostability in compare with vaccines derived from strains of Beijing, Brazil, CCCP, France of Hungary.
本文报道了丹麦卡介苗2株的保存方法。该菌株交替在胆汁马铃薯培养基和苏通马铃薯培养基中培养，培养周期为两周。用该菌株种子制备的冻干疫苗对新生儿具有更好的免疫原性和更低的副作用，并且与来自北京、巴西、苏联、法国和匈牙利菌株的疫苗相比，具有更好的热稳定性。
