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1
Envelope glycoprotein (gp120) from HIV-1 enhances Mycobacterium avium growth in human bronchoalveolar macrophages; an effect mediated by enhanced prostaglandin synthesis.来自HIV-1的包膜糖蛋白（gp120）可促进鸟分枝杆菌在人支气管肺泡巨噬细胞中的生长；这一效应由前列腺素合成增强介导。
Clin Exp Immunol. 1994 Oct;98(1):123-7. doi: 10.1111/j.1365-2249.1994.tb06617.x.
2
Interaction between Mycobacterium avium and human immunodeficiency virus type 1 (HIV-1) in bronchoalveolar macrophages of normal and HIV-1-infected subjects.鸟分枝杆菌与1型人类免疫缺陷病毒（HIV-1）在正常及HIV-1感染受试者支气管肺泡巨噬细胞中的相互作用。
Am J Respir Cell Mol Biol. 1994 Oct;11(4):487-95. doi: 10.1165/ajrcmb.11.4.7917317.
3
Modulation of the effector function of human monocytes for Mycobacterium avium by human immunodeficiency virus-1 envelope glycoprotein gp120.人类免疫缺陷病毒1型包膜糖蛋白gp120对人单核细胞针对鸟分枝杆菌效应功能的调节作用。
J Clin Invest. 1994 Feb;93(2):885-91. doi: 10.1172/JCI117044.
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HIV-1 envelope protein (gp120) inhibits the activity of human bronchoalveolar macrophages against Cryptococcus neoformans.人类免疫缺陷病毒1型包膜蛋白（gp120）可抑制人支气管肺泡巨噬细胞对新型隐球菌的活性。
Am Rev Respir Dis. 1992 Dec;146(6):1434-8. doi: 10.1164/ajrccm/146.6.1434.
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Recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) or tumour necrosis factor-alpha (TNF-alpha) activate human alveolar macrophages to inhibit growth of Mycobacterium avium complex.重组粒细胞-巨噬细胞集落刺激因子（GM-CSF）或肿瘤坏死因子-α（TNF-α）可激活人肺泡巨噬细胞，以抑制鸟分枝杆菌复合体的生长。
Clin Exp Immunol. 1994 Oct;98(1):169-73. doi: 10.1111/j.1365-2249.1994.tb06625.x.
6
Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.人类免疫缺陷病毒重组糖蛋白120是一种有效的干扰素诱导剂。
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Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1.人类免疫缺陷病毒糖蛋白（gp120）诱导单核细胞花生四烯酸代谢产物和白细胞介素1的产生。
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Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.可溶性CD4蛋白与1型人类免疫缺陷病毒及受感染细胞的结合会诱导包膜糖蛋白gp120的释放。
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2189-93. doi: 10.1073/pnas.88.6.2189.
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Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.HIV-1对人巨噬细胞针对荚膜组织胞浆菌效应器功能的调节作用。包膜糖蛋白gp120的作用。
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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.在一种不依赖CD4的HIV-1包膜蛋白中，共受体结合位点的稳定暴露。
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Induction of disseminated Mycobacterium avium in simian AIDS is dependent upon simian immunodeficiency virus strain and defective granuloma formation.在猿猴艾滋病中播散性鸟分枝杆菌的诱导取决于猿猴免疫缺陷病毒株和肉芽肿形成缺陷。
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本文引用的文献

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Mycobacterium avium complex infection and AIDS: advances in theory and practice.鸟分枝杆菌复合群感染与艾滋病：理论与实践进展
Clin Infect Dis. 1993 Jul;17(1):7-20. doi: 10.1093/clinids/17.1.7.
2
Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses.从培养的人T淋巴瘤细胞中分离出的C型逆转录病毒的免疫学特性及其与其他哺乳动物逆转录病毒的比较。
J Virol. 1981 Jun;38(3):906-15. doi: 10.1128/JVI.38.3.906-915.1981.
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Regulation of the immune response by prostaglandins.前列腺素对免疫反应的调节
J Clin Immunol. 1983 Oct;3(4):295-315. doi: 10.1007/BF00915791.
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Inhibition of normal human natural killer cell activity by human immunodeficiency virus synthetic transmembrane peptides.
Cell Immunol. 1988 Aug;115(1):57-65. doi: 10.1016/0008-8749(88)90161-x.
5
Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro.前列腺素E2是精液的一种成分，可在体外促进获得性免疫缺陷综合征病毒的复制。
Proc Natl Acad Sci U S A. 1986 May;83(10):3487-90. doi: 10.1073/pnas.83.10.3487.
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Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.HIV包膜蛋白gp120对CD4 + T细胞功能的抑制作用。
J Immunol. 1988 Dec 1;141(11):3715-7.
7
Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.感染麻风分枝杆菌的巨噬细胞对γ干扰素无反应性的诱导。
Infect Immun. 1988 Aug;56(8):1912-9. doi: 10.1128/iai.56.8.1912-1919.1988.
8
Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1.人类免疫缺陷病毒糖蛋白（gp120）诱导单核细胞花生四烯酸代谢产物和白细胞介素1的产生。
Proc Natl Acad Sci U S A. 1989 Jan;86(2):621-5. doi: 10.1073/pnas.86.2.621.
9
Increased synthesis and production of prostaglandin E2 by monocytes from drug addicts with AIDS.艾滋病吸毒者单核细胞中前列腺素E2的合成与产生增加。
AIDS. 1989 Feb;3(2):91-6. doi: 10.1097/00002030-198902000-00007.
10
Defects in sera from acquired immunodeficiency syndrome (AIDS) patients and from non-AIDS patients with Mycobacterium avium infection which decrease macrophage resistance to M. avium.获得性免疫缺陷综合征（艾滋病）患者以及患有鸟分枝杆菌感染的非艾滋病患者血清中的缺陷，这些缺陷会降低巨噬细胞对鸟分枝杆菌的抵抗力。
Infect Immun. 1989 May;57(5):1445-51. doi: 10.1128/iai.57.5.1445-1451.1989.

来自HIV-1的包膜糖蛋白（gp120）可促进鸟分枝杆菌在人支气管肺泡巨噬细胞中的生长；这一效应由前列腺素合成增强介导。

Envelope glycoprotein (gp120) from HIV-1 enhances Mycobacterium avium growth in human bronchoalveolar macrophages; an effect mediated by enhanced prostaglandin synthesis.

作者信息

Denis M

机构信息

Pulmonary Research Unit, Faculty of Medicine, University of Sherbrooke, Canada.

出版信息

Clin Exp Immunol. 1994 Oct;98(1):123-7. doi: 10.1111/j.1365-2249.1994.tb06617.x.

DOI:10.1111/j.1365-2249.1994.tb06617.x
PMID:7923870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534188/
Abstract

Human bronchoalveolar lavage (BAL) macrophages were obtained from normal human volunteers and infected with an AIDS-associated strain of Mycobacterium avium. Infected cells were exposed to purified envelope glycoprotein (gp120) from HIV-1 or to the recombinant non-glycosylated gp120 fragments PBI-RF and PBI-IIIB. Native gp120 increased Myco. avium growth in human cells from six separate donors, whereas the non-glycosylated fragments of gp120 had no such effect. Moreover, gp120 induced a substantial secretion of prostaglandin E2 (PGE2) from macrophages; inclusion of indomethacin blocked the enhanced permissiveness of infected cells treated with gp120. Soluble CD4 also neutralized the effect of gp120. Overall, these results indicate a role for gp120 in the susceptibility of AIDS patients to Myco. avium infections, mediated by an enhanced PGE2 release.

摘要

人支气管肺泡灌洗（BAL）巨噬细胞取自正常人类志愿者，并感染了与艾滋病相关的鸟分枝杆菌菌株。将感染的细胞暴露于来自HIV-1的纯化包膜糖蛋白（gp120）或重组非糖基化gp120片段PBI-RF和PBI-IIIB。天然gp120增加了来自六个不同供体的人细胞中鸟分枝杆菌的生长，而gp120的非糖基化片段则没有这种作用。此外，gp120诱导巨噬细胞大量分泌前列腺素E2（PGE2）；加入吲哚美辛可阻断用gp120处理的感染细胞增强的易感性。可溶性CD4也中和了gp120的作用。总体而言，这些结果表明gp120在艾滋病患者对鸟分枝杆菌感染的易感性中起作用，这是由增强的PGE2释放介导的。