5-羟色氨酸治疗莱施-奈恩综合征一例的双盲临床试验。
Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.
作者信息
Frith C D, Johnston E C, Joseph M H, Powell R J, Watts R W
出版信息
J Neurol Neurosurg Psychiatry. 1976 Jul;39(7):656-62. doi: 10.1136/jnnp.39.7.656.
Abstract
5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.
摘要
对一例患有强迫性自残行为、手足徐动症以及典型临床生化表现的莱施-奈恩综合征患者，采用双盲法研究了5-羟色氨酸（5-HTP）的治疗效果。5-HTP或安慰剂每两周给药一次，共进行七个治疗周期。5-HTP显著减少了手足徐动症，并有镇静作用，但并未改善患者情绪或减少自残行为。
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