Ciaranello R D, Anders T F, Barchas J D, Berger P A, Cann H M
Child Psychiatry Hum Dev. 1976 Winter;7(2):127-33. doi: 10.1007/BF01464036.
The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, were studied in a boy with the Lesch-Nyhan syndrome. During the course of drug treatment, self-mutilation, crying, sleep state architecture, serum dopamine B-hydroxylase (DBH), and cerebrospinal fluid levels of 5-hydroxyindolylacetic acid and homovanillic acid were studied. Treatment with 5-HTP failed to affect this child's biting behavior. However, the drug significantly reduced irritability as measured by crying time. Moreover, 5-HTP may have affected sleep state architecture, making it more normal in character. Serum DBH levels were normal throughout the study. Neither the patient's mother nor his maternal grandmother showed a hypertensive response on the cold pressor test.
对一名患有莱施-奈恩综合征的男孩，研究了血清素前体5-羟色氨酸（5-HTP）的作用。在药物治疗过程中，对自残行为、哭闹、睡眠状态结构、血清多巴胺β-羟化酶（DBH）以及脑脊液中5-羟吲哚乙酸和高香草酸水平进行了研究。5-HTP治疗未能影响该患儿的咬噬行为。然而，该药物通过哭闹时间衡量，显著降低了易怒情绪。此外，5-HTP可能影响了睡眠状态结构，使其性质更趋正常。在整个研究过程中，血清DBH水平均正常。该患者的母亲及其外祖母在冷加压试验中均未出现高血压反应。
