Sturgiss S N, Dunlop W, Davison J M
Department of Obstetrics and Gynaecology, University of Newcastle-upon-Tyne, Royal Infirmary, UK.
Baillieres Clin Obstet Gynaecol. 1994 Jun;8(2):209-34. doi: 10.1016/s0950-3552(05)80319-0.
In human pregnancy, effective renal plasma flow and glomerular filtration rate increase to levels 50-80% above non-pregnant values. The increments occur shortly after conception, persist throughout the second trimester and reduce slightly in late pregnancy. The hyperfiltration of pregnancy does not seem to be a potentially damaging process, as intraglomerular pressure remains unchanged. The increased excretion of glucose and other nutrients, as well as uric acid and protein, is related in part to altered tubular function. Renal physiology is altered so much in pregnancy that non-pregnant norms cannot be used in antenatal care.
在人类妊娠期间，有效的肾血浆流量和肾小球滤过率增加至比非妊娠时的值高出50 - 80%的水平。这些增加在受孕后不久就会出现，在整个妊娠中期持续存在，并在妊娠晚期略有下降。妊娠时的超滤似乎不是一个潜在的损害过程，因为肾小球内压力保持不变。葡萄糖和其他营养物质以及尿酸和蛋白质排泄的增加部分与肾小管功能改变有关。妊娠期间肾脏生理改变非常大，以至于非妊娠时的标准不能用于产前护理。
