Effects of prostaglandins on the skeleton.

Prostaglandins (PGs), particularly those of the E series, have potent effects on bone resorption in vitro and on bone formation, bone remodeling, and bone modeling in vivo. When given systemically, PGEs have powerful anabolic effects--increasing bone formation rates, bone modeling in the formation mode, and remodeling with a net increase in bone mass. When applied locally, PGE1 increases periosteal bone formation and alveolar bone mass, and appears to promote periodontal soft-tissue regeneration. PGs have potential clinical application in the local restoration or augmentation of bone mass, focal stimulation or bone formation, and the regeneration of soft tissues associated with osseous tissues, such as fibrous and ligamentous insertions into bone.