Oates T W, Cochran D L
University of Texas Health Science Center at San Antonio, USA.
Curr Opin Periodontol. 1996;3:34-44.
The loss of alveolar bone tissue associated with periodontal disease appears to be related to local factors that alter the physiologic balance between bone formation and resorption. Physiologic bone metabolism requires the coupled activities of bone resorption and bone formation. Recent investigations of this coupling phenomenon have been directed at understanding the regulatory mechanisms involved in osteoblast-osteoclast interactions. These regulatory mechanisms utilize multiple cytokines, which function in context with numerous other factors, including cell-cell interactions, extracellular matrix molecules, and levels of differentiation. Local alterations of these factors may disrupt the physiologic balance in bone metabolism and lead to the pathologic loss of alveolar bone. Future strategies for altering bone loss found in the periodontal diseases will be directed at modulating the balance of bone resorption and bone formation at the local site.
与牙周病相关的牙槽骨组织丧失似乎与改变骨形成和吸收之间生理平衡的局部因素有关。生理性骨代谢需要骨吸收和骨形成的协同活动。最近对这种耦合现象的研究旨在了解成骨细胞 - 破骨细胞相互作用中涉及的调节机制。这些调节机制利用多种细胞因子，它们与许多其他因素共同起作用，包括细胞 - 细胞相互作用、细胞外基质分子和分化水平。这些因素的局部改变可能会破坏骨代谢的生理平衡并导致牙槽骨的病理性丧失。未来改变牙周病中骨丧失的策略将针对调节局部部位骨吸收和骨形成的平衡。
