Liu P M, Zhang X M, Wu W, Li J M, Tang Y
Department of Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
Chin Med J (Engl). 1994 May;107(5):375-9.
A comparative study on ventricular electrophysiologic effects of experimental hypothyroidism and chronic oral amiodarone administration was made in canine models, with the application of electrical stimulation and monophasic action potential recording. The results showed similar effects possessed by hypothyroidism and amiodarone, which included prolongations in ventricular repolarization and refractoriness, an increase in ventricular fibrillation threshold, and a decrease in the incidence of reperfusion ventricular fibrillation. The differences were that hypothyroidism primarily lengthened phase 2 repolarization and had no effects on intraventricular conduction time, whereas amiodarone lengthened both phase 2 and phase 3 repolarization and suppressed myocardial conduction velocity.
在犬类模型中，通过电刺激和单相动作电位记录，对实验性甲状腺功能减退和长期口服胺碘酮的心室电生理效应进行了比较研究。结果显示，甲状腺功能减退和胺碘酮具有相似的效应，包括心室复极化和不应期延长、心室颤动阈值增加以及再灌注心室颤动发生率降低。不同之处在于，甲状腺功能减退主要延长2期复极化，对室内传导时间无影响，而胺碘酮则延长2期和3期复极化并抑制心肌传导速度。
