一种新型二氢吡啶类钙拮抗剂对Wistar-Kyoto大鼠静脉容量的影响。

Effects of a novel dihydropyridine calcium antagonist on venous capacitance in Wistar-Kyoto rats.

作者信息

Shiramoto M, Imaizumi T, Endo T, Tagawa T, Kubo T, Tokunaga S, Ando S, Takeshita A

机构信息

Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Drugs Exp Clin Res. 1994;20(2):61-8.

PMID:7924898

Abstract

Calcium antagonists are potent dilators of resistance vessels but do not dilate capacitance vessels. CD832 is a novel dihydropyridine calcium antagonist which has a nitrate moiety in its chemical structure. The authors examined the effects of CD832 on venous capacitance in anesthetized rats. Venous capacitance was assessed by measuring mean circulatory filling pressure (MCFP) at three levels of blood volume. Nitroglycerin decreased and phenylephrine increased MCFP. CD832 did not alter MCFP. After treatment with hexamethonium to prevent reflex venoconstriction, CD832 significantly decreased MCFP but nicardipine (another dihydropyridine calcium antagonist) did not. The magnitude of hypotension caused by CD832 and nicardipine was comparable. The results suggest that CD832 is a unique calcium antagonist which has a venodilator effect.

摘要

钙拮抗剂是阻力血管的强效扩张剂，但不扩张容量血管。CD832是一种新型二氢吡啶类钙拮抗剂，其化学结构中含有硝酸酯部分。作者研究了CD832对麻醉大鼠静脉容量的影响。通过在三个血容量水平测量平均循环充盈压（MCFP）来评估静脉容量。硝酸甘油使MCFP降低，去氧肾上腺素使MCFP升高。CD832未改变MCFP。用六甲铵治疗以防止反射性静脉收缩后，CD832显著降低了MCFP，但尼卡地平（另一种二氢吡啶类钙拮抗剂）未降低。CD832和尼卡地平引起的低血压程度相当。结果表明，CD832是一种具有静脉扩张作用的独特钙拮抗剂。