1,4-二氢吡啶类钙通道拮抗剂普拉地平对大鼠的扩血管作用：与硝苯地平和氨氯地平的比较。

Venodilator effects of pranidipine, a 1,4-dihydropyridine Ca2+ channel antagonist, in rats: comparison with nifedipine and amlodipine.

作者信息

Hirano T, Ohura M, Orito K, Fujiki H, Miyakoda G, Mori T

机构信息

2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., Kawauchi-cho, Japan.

出版信息

Eur J Pharmacol. 1997 Apr 18;324(2-3):201-4. doi: 10.1016/s0014-2999(97)10007-3.

DOI:10.1016/s0014-2999(97)10007-3

PMID:9145772

Abstract

The effects of pranidipine, a dihydropyridine Ca2+ channel antagonist, on mean circulatory filling pressure, an index of body venous tone, were compared with those of other dihydropyridines (nifedipine and amlodipine) and nitroglycerin in anaesthetized hexamethonium- and norepinephrine-treated rats. In this study, the compounds were used at doses having a equi-hypotensive effect. Intravenous bolus injection of pranidipine (10 and 30 microg/kg) significantly decreased mean circulatory filling pressure in a dose-dependent manner, as did nitroglycerin (30 and 100 microg/kg). Nifedipine (30 and 100 microg/kg), however, did not affect mean circulatory filling pressure. Amlodipine (1000 and 3000 microg/kg) decreased mean circulatory filling pressure only at the higher dose. These results suggest that pranidipine has a greater venodilator effect than nifedipine and amlodipine.

摘要

在麻醉的六甲铵和去甲肾上腺素处理的大鼠中，将二氢吡啶类钙通道拮抗剂普拉地平对平均循环充盈压（身体静脉张力指标）的影响与其他二氢吡啶类药物（硝苯地平和氨氯地平）及硝酸甘油的影响进行了比较。在本研究中，这些化合物以具有同等降压效果的剂量使用。静脉推注普拉地平（10和30微克/千克）以剂量依赖性方式显著降低平均循环充盈压，硝酸甘油（30和100微克/千克）也是如此。然而，硝苯地平（30和100微克/千克）对平均循环充盈压没有影响。氨氯地平（1000和3000微克/千克）仅在较高剂量时降低平均循环充盈压。这些结果表明，普拉地平比硝苯地平和氨氯地平具有更强的静脉舒张作用。