Mellinghoff H, Diefenbach C, Bischoff A, Grond S, Buzello W
University Department of Anaesthesiology, Cologne, Germany.
Eur J Anaesthesiol Suppl. 1994;9:20-4.
The dose-response relationship and time course of neuromuscular block following bolus injections of rocuronium was determined in four groups of nine patients each under nitrous oxide-narcotic anaesthesia. Each patient received a total of 800 micrograms kg-1 rocuronium in two divided doses, i.e. 120 and 680, 200 and 600, 250 and 550, or 300 and 500 micrograms kg-1. The respective second dose was injected when, following the first dose, the evoked twitch tension had recovered to 95% of its control value. The mean ED50 and ED95 values, calculated from the first doses, were 103 and 271 micrograms kg-1, respectively. The DUR25 ranged between 11 +/- 4 (200 micrograms kg-1) to 14 +/- 3 min (300 micrograms kg-1) following the first and from 30 +/- 6 (500 micrograms kg-1) to 43 +/- 11 min (680 micrograms kg-1) following the second doses. The recovery index following the second doses varied between 14 +/- 5 (500 micrograms kg-1) and 24 +/- 20 min (600 micrograms kg-1), more than twice as long as following the first doses. We conclude that rocuronium is a muscle relaxant of low potency with an intermediate duration of action.
在氧化亚氮-麻醉剂麻醉下，对四组患者（每组9例）进行了单次注射罗库溴铵后神经肌肉阻滞的剂量-反应关系和时程研究。每位患者分两次共接受800微克/千克的罗库溴铵，即120微克/千克和680微克/千克、200微克/千克和600微克/千克、250微克/千克和550微克/千克或300微克/千克和500微克/千克。当第一剂注射后诱发的抽搐张力恢复到对照值的95%时，注射相应的第二剂。根据第一剂计算的平均ED50和ED95值分别为103微克/千克和271微克/千克。第一剂后DUR25在11±4分钟（200微克/千克）至14±3分钟（300微克/千克）之间，第二剂后在30±6分钟（500微克/千克）至43±11分钟（680微克/千克）之间。第二剂后的恢复指数在14±5分钟（500微克/千克）至24±20分钟（600微克/千克）之间，比第一剂后长两倍多。我们得出结论，罗库溴铵是一种效能较低、作用持续时间中等的肌肉松弛剂。
