单次推注剂量（2倍有效剂量）罗库溴铵的神经肌肉阻滞及插管条件
NEUROMUSCULAR BLOCKADE AND INTUBATION CONDITIONS OF THE SINGLE BOLUS DOSE (2xED) OF ROCURONIUM BROMIDE.
作者信息
Suri Yudhvir, Lamba N S, Krishna Rbm
机构信息
Senior Adviser (Anaesthesiology), Base Hospital, Delhi Cantt.
Classified Specialist Anaesthesiology, 428 Field Ambulance, C/o 56 APO.
出版信息
Med J Armed Forces India. 2000 Jan;56(1):10-12. doi: 10.1016/S0377-1237(17)30080-1. Epub 2017 Jun 8.
Rocuronium bromide (2xED), a new non depolarising neuromuscular blocking drug with rapid onset, intermediate duration of action and cardiostability was studied in open randomised trial in 30 patients. Neuromuscular block was monitored using a Train of Four stimulus by stimulator electrodes placed on the ulnar never close to the wrist. Intubation conditions were assessed subjectively by scoring the jaw relaxation, vocal cord and the response to intubation with same technique of anaesthesia. Clinical recovery (Dur) of neuromuscular blockade was monitored. Haemodynamic changes were recorded. Intubation conditions were clinically acceptable in 99.6% of patients, (excellent 73%; good 26.6%) at 90s. Time to onset (Lag time) of neuromuscular block was 22.5 ± 12.6 sec and average time for the onset of block (maximum effect) was 90.9 ±10.6 sec. The duration of clinical muscular relaxation (25% recovery of twitch height) was 22.4 ± 8.30 min. Stability of cardiocirculatory system was seen.
罗库溴铵（2倍有效剂量）是一种新型非去极化神经肌肉阻滞药物，起效迅速，作用时间中等，且具有心脏稳定性。在30例患者中进行了开放随机试验研究。通过置于靠近手腕的尺神经上的刺激电极，使用四个成串刺激来监测神经肌肉阻滞。采用相同的麻醉技术，通过对下颌松弛度、声带及插管反应进行评分，主观评估插管条件。监测神经肌肉阻滞的临床恢复情况（持续时间）。记录血流动力学变化。90秒时，99.6%的患者插管条件在临床上是可接受的（优73%；良26.6%）。神经肌肉阻滞的起效时间（滞后时间）为22.5±12.6秒，阻滞开始（最大效应）的平均时间为90.9±10.6秒。临床肌肉松弛持续时间（颤搐高度恢复25%）为22.4±8.30分钟。观察到心脏循环系统的稳定性。
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