O'Kelly B, Fiset P, Meistelman C, Ecoffey C
Department of Anaesthesia, Bicetre Hospital, France.
Eur J Anaesthesiol Suppl. 1994;9:57-8.
Rocuronium 0.8 mg kg-1 was given to 22 children between the ages of 3 months and 8 years during anaesthesia with N2O/O2, 60:40, and halothane. Blood samples were collected for 360 min for determination of rocuronium concentrations. The pharmacokinetics were best described by a two-compartment model. Two models were fitted, one proportional to weight and the other adjusted for age. Using the first model, volumes and clearances were all proportional to weight: in the second model, only the volume of the second compartment and clearance from the central compartment were proportional to age. The results do not support the use of body surface area, rather than weight for the calculation of paediatric doses of rocuronium. In this study, the volume of the central compartment was larger than the figure obtained in an adult population.
在使用60:40的N2O/O2和氟烷进行麻醉期间，给22名年龄在3个月至8岁之间的儿童静脉注射了0.8毫克/千克的罗库溴铵。采集血样360分钟以测定罗库溴铵浓度。药代动力学用二室模型描述最佳。拟合了两个模型，一个与体重成正比，另一个根据年龄进行了调整。使用第一个模型，容积和清除率均与体重成正比；在第二个模型中，只有第二室的容积和中央室的清除率与年龄成正比。结果不支持使用体表面积而非体重来计算小儿罗库溴铵剂量。在本研究中，中央室的容积大于成年人群中的数值。
