Xue F, Luo L, Sun B, Zou Q
Plastic Surgery Hospital, CAMS and PUMC, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1996 Apr;18(2):121-5.
Twenty-four patients scheduled for elective plastic surgery were selected to study the pharmacokinetics of pancuronium bromide under enflurane anesthesia. The patients were divided into three groups by their ages; Group 1 consisted of 5 infants (0.75-2.95 years); Group 2 contained 13 children (4-14 years); Group 3 included 6 adults (16-27 years). An improved fluorimetric assay was used to measure the plasma concentrations of pancuronium bromide after administration of pancuronium bromide at a dose of 100 micrograms/kg. The results showed that the disposition of pancuronium bromide may be best described mathematically by a two-compartment open model in all patients. The younger the patients, the larger the distribution volumes and the higher the Cl. There were significant differences among the three groups with regard to V1, V2, Vdss, Cl, AUC. The T1/2 beta and MRT were longer in Group 1 than in Group 2 and Group 3.
选取24例计划接受择期整形手术的患者，研究安氟醚麻醉下潘库溴铵的药代动力学。根据年龄将患者分为三组；第1组包括5名婴儿（0.75 - 2.95岁）；第2组包含13名儿童（4 - 14岁）；第3组包括6名成年人（16 - 27岁）。采用改进的荧光分析法测定以100微克/千克的剂量给予潘库溴铵后其血浆浓度。结果表明，在所有患者中，潘库溴铵的处置情况用二室开放模型进行数学描述最为合适。患者年龄越小，分布容积越大，清除率越高。三组在V1、V2、Vdss、Cl、AUC方面存在显著差异。第1组的T1/2β和MRT比第2组和第3组长。
