Bevan D R
University of British Columbia, Faculty of Medicine, Department of Anaesthesia, Vancouver, Canada.
Eur J Anaesthesiol Suppl. 1994;9:87-91.
Neuromuscular blocking drugs can be divided into those that are: (i) excreted entirely by the kidney; (ii) predominantly by the kidney but also by the liver; (iii) mainly by the liver but also by the kidney or; (iv) removed by other metabolic pathways. Rocuronium is mainly excreted by the liver and pharmacokinetic and pharmacodynamic studies in humans suggest that its duration of action may be prolonged to a greater extent in patients with hepatic disease than in patients with renal disease. The effect is likely to be modest and not a contra-indication to its use.
（i）完全经肾脏排泄；（ii）主要经肾脏排泄，但也经肝脏排泄；（iii）主要经肝脏排泄，但也经肾脏排泄；或（iv）通过其他代谢途径消除。罗库溴铵主要经肝脏排泄，人体药代动力学和药效学研究表明，与肾病患者相比，肝病患者使用罗库溴铵时其作用持续时间可能会延长得更多。这种影响可能较小，并非使用该药的禁忌证。
