Smeulers N J, Wierda J M, van den Broek L, Gallandat Huet R C, Hennis P J
Research Group for Experimental Anesthesiology and Clinical Pharmacology, University Hospital, Groningen, The Netherlands.
Eur J Anaesthesiol Suppl. 1995 Sep;11:91-4.
In 10 patients scheduled for elective coronary artery bypass grafting under midazolam-sufentanil anaesthesia, the influence of hypothermia on the plasma concentration-response and biodisposition of rocuronium were investigated. Neuromuscular function was monitored mechanomyographically. Plasma and urine concentrations of rocuronium were determined by high performance liquid chromatography. Hypothermic cardiopulmonary bypass prolonged the duration of action of maintenance doses and altered the plasma concentration-response relationship. The elimination and distribution half-lives, following the last maintenance dose after rewarming, and the urinary excretion of rocuronium were similar to values obtained during normothermia. A diminished hepatic uptake and storage in the liver of rocuronium during hypothermia may explain the more pronounced prolongation of the duration compared to that of other steroidal neuromuscular blocking agents.
在10例计划在咪达唑仑-舒芬太尼麻醉下进行择期冠状动脉搭桥术的患者中，研究了低温对罗库溴铵血浆浓度-效应及生物处置的影响。采用肌动图法监测神经肌肉功能。通过高效液相色谱法测定罗库溴铵的血浆和尿液浓度。低温体外循环延长了维持剂量的作用持续时间，并改变了血浆浓度-效应关系。复温后最后一次维持剂量后的消除半衰期和分布半衰期以及罗库溴铵的尿排泄与正常体温期间获得的值相似。低温期间罗库溴铵在肝脏中的摄取和储存减少，这可能解释了与其他甾体类神经肌肉阻滞剂相比，其作用持续时间延长更为明显的原因。
