使用罗库溴铵输注的闭环反馈控制来定量罗库溴铵与依托咪酯、芬太尼、咪达唑仑、丙泊酚、硫喷妥钠和异氟烷的相互作用。
Quantitation of the interaction of rocuronium bromide with etomidate, fentanyl, midazolam, propofol, thiopentone, and isoflurane using closed-loop feedback control of infusion of rocuronium.
作者信息
Olkkola K T, Tammisto T
机构信息
Department of Anaesthesia, University of Helsinki, Finland.
出版信息
Eur J Anaesthesiol Suppl. 1994;9:99-100.
Sixty patients were randomly assigned to one of six groups (n = 10 in each case) in which anaesthesia was induced and maintained with etomidate, fentanyl, midazolam, propofol or with thiopentone and N2O, or isoflurane and N2O. After obtaining control measurements, rocuronium 0.6 mg kg-1 was given for intubation followed by an infusion, controlled by closed-loop feedback at 90% block. The steady-state rates of infusion were (in the same order) 0.64 +/- 0.22, 0.60 +/- 0.15, 0.61 +/- 0.21, 0.67 +/- 0.31, 0.63 +/- 0.15 and 0.39 +/- 0.17 mg kg-1 h-1 (Mean +/- SD). The intravenous agents did not interact with recuronium to any clinically significant degree. Isoflurane reduced the requirements by 35-40%.
60名患者被随机分为6组（每组n = 10），分别使用依托咪酯、芬太尼、咪达唑仑、丙泊酚，或硫喷妥钠与N₂O，或异氟烷与N₂O进行麻醉诱导和维持。在获得对照测量值后，给予0.6 mg·kg⁻¹罗库溴铵进行插管，随后进行输注，通过闭环反馈控制在90%阻滞水平。输注的稳态速率（按相同顺序）分别为0.64±0.22、0.60±0.15、0.61±0.21、0.67±0.31、0.63±0.15和0.39±0.17 mg·kg⁻¹·h⁻¹（均值±标准差）。静脉用药与罗库溴铵之间在临床上无显著相互作用。异氟烷使需求量降低了35% - 40%。
Zotero 插件