Khuenl-Brady K S, Sparr H, Pühringer F, Agoston S
Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens-University of Innsbruck, Austria.
Eur J Anaesthesiol Suppl. 1995 Sep;11:79-80.
Thirty patients requiring elective ventilation in the ICU received either intermittent boluses (25 patients) or a continuous infusion (five patients) of rocuronium. Degree of block was monitored by train-of-four stimuli and maintained at one twitch either observed or palpated. All patients were sedated with intermittent doses or an infusion of 0.14-0.4 microgram kg-1 h-1 of midazolam and received a continuous infusion of either sufentanil or fentanyl (0.25-2.0 micrograms kg-1 h-1). Control of ventilation was better with the continuous infusion of rocuronium, but these patients also had a more intense block receiving 9.9 +/- 1.3 micrograms kg-1 min-1 as compared to 6.4 +/- 2.3 micrograms kg-1 min-1 in the bolus group. Elimination half-time, volume of distribution at steady-state, and mean residence time were significantly greater than in surgical patients receiving comparable infusions, but plasma clearance was similar.
30例在重症监护病房（ICU）需要择期通气的患者接受了罗库溴铵的间歇性推注（25例患者）或持续输注（5例患者）。通过四个成串刺激监测阻滞程度，并维持在可观察到或可触知的单颤搐水平。所有患者均用间歇性剂量或0.14 - 0.4微克/千克/小时的咪达唑仑输注进行镇静，并接受舒芬太尼或芬太尼的持续输注（0.25 - 2.0微克/千克/小时）。持续输注罗库溴铵时通气控制更好，但这些患者的阻滞也更强，持续输注组接受9.9±1.3微克/千克/分钟，而推注组为6.4±2.3微克/千克/分钟。消除半衰期、稳态分布容积和平均驻留时间显著长于接受类似输注的手术患者，但血浆清除率相似。
