Oliveri M B, Mautalen C, Bustamante L, Gómez García V
Sección Osteopatías Médicas, Hospital de Clínicas, Universidad de Buenos Aires, Argentina.
Eur J Clin Nutr. 1994 Jun;48(6):397-401.
Since exposure to sunlight is the main source of vitamin D in human beings and skin photosynthesis decreases markedly as the latitude increases, we studied the changes in serum 25-hydroxyvitamin D (25(OH)D) levels in young healthy men who lived in the Antarctic Continent during 1 year.
Blood was drawn in the fasting state every 2 months from March 1990 to January 1991 to determine the serum levels of calcium, alkaline phosphatase and 25(OH)D.
19 healthy volunteers, who left Buenos Aires (34 degrees S) during the 1990 summer, arriving at the Antarctic bases at the end of January (Belgrano) and in mid-March (San Martín) and stayed there up to summer 1991.
Serum calcium did not change significantly throughout the year. Serum alkaline phosphatase levels were not different comparing the beginning to the end of the year, but autumn and winter levels were lower (P < 0.05). At Belgrano Base the serum 25(OH)D levels (ng/ml) decreased from (mean +/- SD) 18.7 +/- 7.4 (March) to 10.0 +/- 4.3 (July) (P < 0.005) and did not recover for the rest of the year. At San Martín Base the serum 25(OH)D levels descended from 22.0 +/- 5.4 in March to 12.2 +/- 3.7 in August (P < 0.02) and did not increase even at the beginning of summer (January) except in two men with frequent outdoor activities.
The levels of 25(OH)D of healthy men living in the Antarctic continent decreased to approximately 46% of the initial values and did not increase even at the onset of summer. Further studies should determine the effect of these changes upon calcium-regulating hormones and bone metabolism.
由于阳光照射是人类维生素D的主要来源，且随着纬度增加皮肤光合作用显著降低，我们研究了在南极大陆生活1年的年轻健康男性血清25-羟基维生素D（25(OH)D）水平的变化。
从1990年3月至1991年1月，每2个月在空腹状态下采集血液，以测定血清钙、碱性磷酸酶和25(OH)D水平。
19名健康志愿者，于1990年夏季离开布宜诺斯艾利斯（南纬34度），1月底抵达南极基地（贝尔格拉诺），3月中旬抵达（圣马丁），并在那里停留至1991年夏季。
血清钙全年无显著变化。血清碱性磷酸酶水平年初与年末无差异，但秋冬季节水平较低（P<0.05）。在贝尔格拉诺基地，血清25(OH)D水平（ng/ml）从（均值±标准差）18.7±7.4（3月）降至10.0±4.3（7月）（P<0.005），且在当年剩余时间未恢复。在圣马丁基地，血清25(OH)D水平从3月的22.0±5.4降至8月的12.2±3.7（P<0.02），即使在夏季初（1月）也未升高，仅有两名经常进行户外活动的男性除外。
生活在南极大陆的健康男性25(OH)D水平降至初始值的约46%，即使在夏季开始时也未升高。进一步研究应确定这些变化对钙调节激素和骨代谢的影响。
