Oliveri M B, Ladizesky M, Somoza J, Martínez L, Mautalen C
Laboratorio de Osteopatías médicas, Hospital de Clínicas, UBA, Argentina.
Medicina (B Aires). 1990;50(4):310-4.
Public Health Annals recording diagnosis of nutritional rickets in patients admitted in Public Hospitals disclosed that from birth to age 14, in the period 1980-1981, the incidence was 2.7 higher in the Patagonia (latitude 39 degrees S to 55 degrees S) compared with the Pampeana Region and 8.5 higher than in the rest of the country. After informed parental consent 37 healthy children of Buenos Aires (34 degrees S) with an age of (Av +/- 1 SD) 7.0 +/- 1.2 years, 29 with an age of 13.1 +/- 1.5 years and 63 of Ushuaia (55 degrees S) with an age of 7.1 +/- 0.8 years were studied at the end of winter (August). Serum levels of 25-OH-D were as follows (mean +/- SE): Buenos Aires: 21.1 +/- 2.03 ng/ml (Average: seven years old), 19.0 +/- 1.18 ng/ml (children of thirteen years old) and Ushuaia: 9.3 +/- 0.64 ng/ml (p less than 0.001) (Fig. 2). Serum levels were below 8 ng/ml in 52% of the children in Ushuaia but only in 9% in Buenos Aires. Serum calcium and alkaline phosphatase levels were similar in the two groups but serum phosphate was higher in Ushuaia (Table 1). The calcium intake was greater in Ushuaia (811 +/- 49 mg/day) than in Buenos Aires (634 +/- 61 mg/day) and was correlated with 25-OH-D levels in children of Ushuaia (r = 0.50, p less than 0.001) but not in Buenos Aires (r = 0.08). The main source of calcium intake was vitamin D fortified milk. These results disclosed a significantly diminished level of serum 25-OH-D in Ushuaia.(ABSTRACT TRUNCATED AT 250 WORDS)
《公共卫生年鉴》记录了公立医院收治患者的营养性佝偻病诊断情况，结果显示，在1980 - 1981年期间，从出生到14岁，巴塔哥尼亚地区（南纬39度至55度）的发病率比潘帕斯地区高2.7倍，比该国其他地区高8.5倍。在获得家长知情同意后，对布宜诺斯艾利斯（南纬34度）的37名健康儿童（年龄为（平均±标准差）7.0±1.2岁）、29名年龄为13.1±1.5岁的儿童以及乌斯怀亚（南纬55度）的63名年龄为7.1±0.8岁的儿童在冬季末（8月）进行了研究。血清25 - 羟基维生素D水平如下（平均值±标准误）：布宜诺斯艾利斯：21.1±2.03纳克/毫升（平均：7岁儿童），19.0±1.18纳克/毫升（13岁儿童）；乌斯怀亚：9.3±0.64纳克/毫升（p＜0.001）（图2）。乌斯怀亚52%的儿童血清水平低于8纳克/毫升，而布宜诺斯艾利斯仅为9%。两组的血清钙和碱性磷酸酶水平相似，但乌斯怀亚的血清磷更高（表1）。乌斯怀亚的钙摄入量（811±49毫克/天）高于布宜诺斯艾利斯（634±61毫克/天），且与乌斯怀亚儿童的25 - 羟基维生素D水平相关（r = 0.50，p＜0.001），而在布宜诺斯艾利斯则无相关性（r = 0.08）。钙的主要摄入来源是维生素D强化牛奶。这些结果表明，乌斯怀亚的血清25 - 羟基维生素D水平显著降低。（摘要截取自250字）
