Matsumoto Y, Hiromatsu K, Sakai T, Kobayashi Y, Kimura Y, Usami J, Shinzato T, Maeda K, Yoshikai Y
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Eur J Immunol. 1994 Oct;24(10):2441-5. doi: 10.1002/eji.1830241027.
Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation-induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co-stimulation with LFA-1 plays a key role in the choice between the two fates, differentiating between alpha beta and gamma delta T cells. Peripheral gamma delta. T cells but not alpha beta T cells undergo apoptosis upon co-cross-linking of TcR and LFA-1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of gamma delta T cells is inducible by combined stimuli independent of the Fas-mediated pathway.
通过T细胞受体（TcR）刺激T细胞会启动激活途径，而矛盾的是，这也可能导致激活诱导的细胞死亡。许多因素影响受刺激细胞做出表现出其中一种或另一种结果的决定。在这里，我们表明与LFA-1共刺激在这两种命运的选择中起关键作用，区分αβ和γδ T细胞。在MRL lpr/lpr小鼠以及+/+小鼠中，外周γδ T细胞而非αβ T细胞在TcR和LFA-1共交联后会发生凋亡。我们的结果表明，γδ T细胞的凋亡可由独立于Fas介导途径的联合刺激诱导。
