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MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus.
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Activation with superantigens induces programmed death in antigen-primed CD4+ class II+ major histocompatibility complex T lymphocytes via a CD11a/CD18-dependent mechanism.
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Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement.
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