溴隐亭（CB - 154）治疗对高催乳素血症成年雄性大鼠交配行为的影响。

Effects of bromocriptine (CB-154) treatment on copulatory behavior in hyperprolactinemic adult male rats.

作者信息

Tohei A, Saito T R, Hokao R, Furudate S, Takahashi K W

机构信息

Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.

出版信息

Jikken Dobutsu. 1994 Jul;43(3):427-31. doi: 10.1538/expanim1978.43.3_427.

DOI:10.1538/expanim1978.43.3_427

PMID:7925634

Abstract

Adult male rats received pituitary transplantations to induce hyperprolactinemia. Some of those had bromocriptine (CB-154) treatment, and the other had vehicle (saline) as control. The grafted animals with vehicle exhibited significantly more suppression than sham operated animals. While the hyperprolactinemic rats treated with CB-154 showed no significantly more suppression of copulatory behavior than sham operated control. In the grafted animal without CB-154 treatment, the concentration of serum PRL was significantly higher than in sham operated controls. There were no significant differences in adrenal weight and serum levels of gonadotropin between grafted and control groups. These results may imply that PRL has direct actions on central nervous system (CNS) and inhibits copulatory behavior in hyperprolactinemic male rats.

摘要

成年雄性大鼠接受垂体移植以诱导高催乳素血症。其中一些大鼠接受溴隐亭（CB - 154）治疗，另一些则接受赋形剂（生理盐水）作为对照。接受赋形剂的移植动物比假手术动物表现出更明显的抑制作用。而接受CB - 154治疗的高催乳素血症大鼠与假手术对照组相比，在交配行为抑制方面并无显著差异。在未接受CB - 154治疗的移植动物中，血清催乳素浓度显著高于假手术对照组。移植组和对照组之间肾上腺重量和促性腺激素血清水平无显著差异。这些结果可能意味着催乳素对中枢神经系统（CNS）有直接作用，并抑制高催乳素血症雄性大鼠的交配行为。