Elsworth J D, al-Tikriti M S, Sladek J R, Taylor J R, Innis R B, Redmond D E, Roth R H
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
Exp Neurol. 1994 Apr;126(2):300-4. doi: 10.1006/exnr.1994.1068.
This preliminary study demonstrates by in vitro autoradiography the value of novel radiolabeled cocaine analogs to characterize the neurochemical identity and measure the density and growth of fetal ventral mesencephalic cells transplanted to the caudate nucleus of the adult MPTP-treated monkey. Two cocaine derivatives were used, one with extremely high affinity for both dopamine and serotonin transporters and one which was selective for the dopamine transporter. The results suggest that the transplantation procedure was able to increase the density of transporter sites in most of the caudate nucleus, although the proportion of dopaminergic and serotonergic fibers may have been altered from normal.
这项初步研究通过体外放射自显影证明了新型放射性标记可卡因类似物在表征神经化学特性以及测量移植到成年MPTP处理猴尾状核的胎儿腹侧中脑细胞的密度和生长方面的价值。使用了两种可卡因衍生物，一种对多巴胺和血清素转运体都具有极高的亲和力，另一种对多巴胺转运体具有选择性。结果表明，移植程序能够增加大部分尾状核中转运体位点的密度，尽管多巴胺能和血清素能纤维的比例可能已偏离正常水平。
