Williams M B, Jope R S
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham 35294.
Exp Neurol. 1994 Sep;129(1):169-73. doi: 10.1006/exnr.1994.1158.
The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, s.c.) and centrally administered anisomycin (300 micrograms/10 microliters, i.c.v.) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, s.c.) completely blocked lithium-pilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
测试了两种蛋白质合成抑制剂环己酰亚胺和茴香霉素对锂和毛果芸香碱联合给药诱导的大鼠癫痫发作的影响。全身注射环己酰亚胺（2mg/kg，皮下注射）和脑室内注射茴香霉素（300μg/10μL，脑室内注射）使癫痫发作起始和癫痫持续状态的潜伏期延长了一倍，而外周注射茴香霉素（50mg/kg，皮下注射）则完全阻断了锂-毛果芸香碱诱导的癫痫发作。这些结果表明，癫痫发作的起始需要蛋白质合成。
