Furukawa Y, Cook I J, Panagopoulos V, McEvoy R D, Sharp D J, Simula M
Department of Gastroenterology, Royal Adelaide Hospital, University of Adelaide, Australia.
Gastroenterology. 1994 Nov;107(5):1372-81. doi: 10.1016/0016-5085(94)90539-8.
BACKGROUND/AIMS: The precise relationships among colonic motor patterns, depth of sleep, and awakening are incompletely understood. The aim of this study was to correlate human colonic motor patterns with sleep stage, nocturnal arousals, and waking.
We monitored sleep and correlated sleep stage, arousals, and waking with pressures (area under curve and propagating contractions) recorded from the entire colon in 11 healthy volunteers.
Propagating contraction frequency (P = 0.01) and area under the curve (P = 0.001) were significantly reduced at night. There was a highly significant correlation between depth of sleep and suppression of area under curve (P = 0.001) and propagating contraction frequency (P = 0.0001). Propagating contractions were eliminated during slow-wave sleep. During rapid eye movement sleep, colonic pressure and propagating contraction frequency increased sharply to levels comparable with those found in stage 2 sleep. Transient arousal from stable sleep, with or without waking, was a potent and immediate stimulus for colonic propagating contractions.
Sleep per se has a profound inhibitory effect on propagating and nonpropagating activity and is the major determinant of diurnal variation of colonic motility. Propagating contractions are eliminated in slow-wave sleep. Rapid eye movement sleep, arousals, and waking have immediate stimulatory effects on colonic motility.
背景/目的：结肠运动模式、睡眠深度和觉醒之间的确切关系尚未完全明了。本研究的目的是将人类结肠运动模式与睡眠阶段、夜间觉醒及清醒状态相关联。
我们监测了11名健康志愿者的睡眠情况，并将睡眠阶段、觉醒及清醒状态与整个结肠记录的压力（曲线下面积和推进性收缩）相关联。
夜间推进性收缩频率（P = 0.01）和曲线下面积（P = 0.001）显著降低。睡眠深度与曲线下面积抑制（P = 0.001）及推进性收缩频率抑制（P = 0.0001）之间存在高度显著的相关性。在慢波睡眠期间，推进性收缩消失。在快速眼动睡眠期间，结肠压力和推进性收缩频率急剧增加至与2期睡眠时相当的水平。从稳定睡眠状态的短暂觉醒，无论是否伴有清醒，都是结肠推进性收缩的有力且即时的刺激因素。
睡眠本身对推进性和非推进性活动具有深远的抑制作用，并且是结肠运动昼夜变化的主要决定因素。在慢波睡眠中推进性收缩消失。快速眼动睡眠、觉醒及清醒状态对结肠运动具有即时的刺激作用。
