中枢血管加压素在心血管调节中的作用：脱水和性别的影响。

Role of central vasopressin in cardiovascular regulation: effect of dehydration and sex.

作者信息

Toba K, Ouchi Y, Liang J, Akishita M, Orimo H

机构信息

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Gerontology. 1994;40 Suppl 2:16-22. doi: 10.1159/000213623.

DOI:10.1159/000213623

PMID:7926862

Abstract

The present study was performed to evaluate the role of central vasopressin in cardiovascular regulation. First, a novel vasopressin V1 antagonist (OPC21268) was injected intracerebroventricularly in conscious rats. In water-deprived animals, the mean arterial blood pressure (MABP) and heart rate were significantly decreased compared with euhydrated control rats. There was, however, no significant difference in the concentration of vasopressin in the perfusate of cerebrospinal fluid between groups. Second, vasopressin was intracerebroventricularly injected in male and female homozygous Brattleboro rats. The increase in MABP was greater in males than in females. These results suggest that central vasopressin is involved in blood pressure regulation in pathophysiological states.

摘要

本研究旨在评估中枢血管加压素在心血管调节中的作用。首先，将一种新型血管加压素V1拮抗剂（OPC21268）脑室内注射到清醒大鼠体内。在缺水动物中，与水合正常的对照大鼠相比，平均动脉血压（MABP）和心率显著降低。然而，两组脑脊液灌流液中血管加压素的浓度没有显著差异。其次，将血管加压素脑室内注射到雄性和雌性纯合布拉特洛伯大鼠体内。MABP的升高在雄性大鼠中比雌性大鼠更大。这些结果表明，中枢血管加压素在病理生理状态下参与血压调节。