Moglia A, Lorini R, D'Annunzio G, Lanzi G, Berardinelli A, Zandrini C
Department of Child Neuropsychiatry-C. Mondino Institute, Pavia, Italy.
Funct Neurol. 1994 Mar-Apr;9(2):75-82.
We investigated 82 unselected insulin dependent diabetes mellitus children and adolescents by clinical and electrophysiological evaluation to assess the frequency of diabetic neuropathy and to relate the results to age and height of patients, duration of illness and degree of metabolic control. Clinical abnormalities were found in about 1/3 of patients: these signs of diabetic neuropathy were related to the age and the duration of diabetes but not to the degree of metabolic control. Neurophysiological study showed alterations, especially of sensory nerve conduction. These results were seen to be related to height and age of patients and duration of illness but not to the degree of metabolic control, probably due to the young age of the patients. Our study confirms that diabetic neuropathy is a heterogeneous disorder that may be caused by the interaction of host susceptibility and vascular, metabolic and perhaps environmental components also in diabetic children.
我们通过临床和电生理评估对82名未经挑选的胰岛素依赖型糖尿病儿童及青少年进行了调查，以评估糖尿病神经病变的发生率，并将结果与患者的年龄、身高、病程及代谢控制程度相关联。约1/3的患者存在临床异常：这些糖尿病神经病变的体征与糖尿病的年龄及病程相关，但与代谢控制程度无关。神经生理学研究显示存在改变，尤其是感觉神经传导方面。这些结果被认为与患者的身高、年龄及病程有关，但与代谢控制程度无关，这可能是由于患者年龄较小。我们的研究证实，糖尿病神经病变是一种异质性疾病，在糖尿病儿童中可能也是由宿主易感性与血管、代谢以及可能的环境因素相互作用所致。
