Cenesiz Funda, Tur Birkan Sonel, Tezic Tahsin, Gurer Yavuz
Department of Pediatric Endocrinology, Dr. Sami Ulus Children Health and Diseases Training and Research Hospital, Ankara, Turkey.
Indian J Pediatr. 2003 Dec;70(12):945-51. doi: 10.1007/BF02723816.
To determine the incidence of peripheral neuropathy in children suffering Insulin Dependent Diabetes Mellitus (IDDM) as well as to determine the relationship between other criteria of the disease and neuropathy.
40 children (17 males, mean age 11.9 years) suffering IDDM and receiving insulin therapy involving two injections a day and 30 healthy children (17 males, mean age 11.7 years) were included in the study. They were inquired about their demographical characteristics as well as the presence of neurological symptoms. Their detailed neurological examinations were conducted. Their glycemic control values (Hb A1C) were recorded, and their nerve conduction studies were performed from right upper and lower extremities.
All nerve conduction values of children with IDDM were found to be significantly lower (p<0.0001) as compared to the control group. 60% of diabetic children (n=24) were found to suffer peripheral neuropathy. Statistically significant relationships were found between the glycemic control values and the peroneal, sural, tibial, ulnar and median nerve conduction velocities, and also between the duration of disease and the peroneal, sural, tibial and median nerve conduction velocities.
The peripheral neuropathy is rather a frequently observed complication in diabetic children. The duration of disease and impaired glycemic control play an important role in the development of neuropathy. The introduction of new methods designed to ensure better glycemic control will reduce the incidence of the complication.
确定胰岛素依赖型糖尿病（IDDM）患儿周围神经病变的发生率，并确定该疾病的其他标准与神经病变之间的关系。
本研究纳入40例患有IDDM且接受每日两次胰岛素注射治疗的儿童（17例男性，平均年龄11.9岁）以及30例健康儿童（17例男性，平均年龄11.7岁）。询问他们的人口统计学特征以及神经症状的存在情况。对他们进行详细的神经学检查。记录他们的血糖控制值（糖化血红蛋白），并对其右上肢和下肢进行神经传导研究。
发现IDDM患儿的所有神经传导值与对照组相比均显著降低（p<0.0001）。发现60%的糖尿病患儿（n = 24）患有周围神经病变。在血糖控制值与腓总神经、腓肠神经、胫神经、尺神经和正中神经传导速度之间，以及疾病持续时间与腓总神经、腓肠神经、胫神经和正中神经传导速度之间发现了具有统计学意义的关系。
周围神经病变是糖尿病患儿中相当常见的并发症。疾病持续时间和血糖控制受损在神经病变的发展中起重要作用。引入旨在确保更好血糖控制的新方法将降低该并发症的发生率。
