Hojo H, Kainuma Y, Kunori T, Wachi E, Wakasa H
Department of Pathology I, Fukushima Medical College, Japan.
Fukushima J Med Sci. 1993 Dec;39(2):77-87.
We reported clinicopathological, histopathological and immunohistological features of two suggestive cases with post transfusion graft-versus-host disease (GVHD) and examined. In addition, we have declared histopathologic characteristics of acute and chronic GVHD with literatural consideration. On the basis of a review of two cases, we came to the following conclusion; It is implied that early lymphoid proliferation may be useful to make a diagnosis of acute GVHD. Case 2 had pathological confirmation of acute GVHD in the liver and small intestine. In the liver, a damage of interlobular bile ducts and T lymphocytes infiltration close to ducts were the most specific feature of acute GVHD. From an immunohistological study in case 2, it was confirmed that abnormal expression of HLA-DR antigen and the appearance of activated T lymphocytes played an important role in the development of GVHD reaction in the liver.
我们报告了两例疑似输血后移植物抗宿主病（GVHD）病例的临床病理、组织病理和免疫组织学特征并进行了检查。此外，我们结合文献考量阐述了急性和慢性GVHD的组织病理学特征。基于对两例病例的回顾，我们得出以下结论：早期淋巴细胞增殖可能有助于急性GVHD的诊断。病例2在肝脏和小肠有急性GVHD的病理证实。在肝脏中，小叶间胆管损伤和靠近胆管的T淋巴细胞浸润是急性GVHD最具特异性的特征。通过对病例2的免疫组织学研究证实，HLA-DR抗原的异常表达和活化T淋巴细胞的出现，在肝脏GVHD反应的发生中起重要作用。
