Kimura A, Yamakawa R, Ushijima K, Fujisawa T, Kuriya N, Kato H, Inokuchi T, Mahara R, Kurosawa T, Tohma M
Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Hepatology. 1994 Oct;20(4 Pt 1):819-24. doi: 10.1002/hep.1840200408.
Fetal bile acids (1 beta-hydroxylated, 6 alpha-hydroxylated and unsaturated bile acids), especially 1 beta, 3 alpha,7 alpha, 12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid (CA-1 beta-ol), have been detected in urine and feces early in life. To investigate whether a fetal pathway of bile acid synthesis exists in infancy, we measured the concentrations of bile acids in the urine, meconium and feces from normal newborns and infants by means of gas chromatography-mass spectrometry. The mean ratio of total bile acids to creatinine in urine increased between birth and 7 days and then gradually decreased; however, the concentration of total bile acids in urine remained significantly higher than that in adult urine until 3 mo of age. The main urinary bile acid was CA-1 beta-ol, and substantial amounts of fetal bile acids were detected in urine until 3 mo of age. The ratio of cholic acid to chenodeoxycholic acid was abnormally low in meconium (mean, 0.44; range, 0.19 to 0.74), and hyocholic acid constituted 19.3% of total bile acids. The mean total bile acid content of feces decreased between birth and 7 days of age and thereafter increased. The mean percentage of fetal bile acids in feces decreased after birth, but substantial amounts were present in feces until 1 mo of age.(ABSTRACT TRUNCATED AT 250 WORDS)
胎儿胆汁酸（1β-羟基化、6α-羟基化和不饱和胆汁酸），尤其是1β、3α、7α、12α-四羟基-5β-胆烷-24-酸（CA-1β-ol），在生命早期的尿液和粪便中已被检测到。为了研究婴儿期是否存在胎儿胆汁酸合成途径，我们通过气相色谱-质谱法测量了正常新生儿和婴儿尿液、胎粪及粪便中的胆汁酸浓度。出生至7天期间，尿液中总胆汁酸与肌酐的平均比值升高，随后逐渐下降；然而，直至3月龄，尿液中总胆汁酸浓度仍显著高于成人尿液。尿液中的主要胆汁酸是CA-1β-ol，直至3月龄，尿液中均可检测到大量胎儿胆汁酸。胎粪中胆酸与鹅去氧胆酸的比值异常低（平均值为0.44；范围为0.19至0.74），猪胆酸占总胆汁酸的19.3%。出生至7日龄期间，粪便中总胆汁酸含量平均下降，之后升高。粪便中胎儿胆汁酸的平均百分比出生后下降，但直至1月龄，粪便中仍存在大量胎儿胆汁酸。（摘要截选于250词）
