中性粒细胞减少症和自然杀伤细胞缺乏症中针对一种58kD蛋白的自身抗体
[Autoantibodies against a 58 kD protein in neutropenia and NK cell deficiency].
作者信息
Witte T, Bode F M, Schmidt R E
机构信息
Abteilung für Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
出版信息
Immun Infekt. 1994 Feb;22(1):28-9.
PMID:7927461
Abstract
An autoantibody against a 58 kD protein on granulocytes, activated NK cells and a subpopulation of B cells was detected in a patient with neutropenia and NK cell deficiency. The patient suffered from recurrent mucocutaneous candidosis and pharyngitis. After 18 months, a spontaneous remission of neutropenia and NK cell deficiency was observed, the autoantibody disappeared from the serum.
摘要
在一名患有中性粒细胞减少症和自然杀伤细胞（NK细胞）缺乏症的患者体内，检测到一种针对粒细胞、活化NK细胞及B细胞亚群上一种58kD蛋白的自身抗体。该患者反复出现黏膜皮肤念珠菌病和咽炎。18个月后，观察到中性粒细胞减少症和NK细胞缺乏症出现自发缓解，血清中的自身抗体消失。
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