与小鼠移植物抗宿主反应不同阶段相关的细胞因子产生差异
Differential cytokine production associated with distinct phases of murine graft-versus-host reaction.
作者信息
Garside P, Reid S, Steel M, Mowat A M
机构信息
Department of Immunology, University of Glasgow, Western Infirmary.
出版信息
Immunology. 1994 Jun;82(2):211-4.
Abstract
Previous studies which demonstrated that cytokines such as interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are essential for the development of graft-versus-host reaction (GvHR) did not establish whether the individual cytokines were responsible for distinct features of the disease. In this report, we show that IFN-gamma production is associated with the early proliferative phase of the disease, whereas the late, destructive phase correlates with production of TNF-alpha. These studies may assist in the development of specific immunotherapies aimed at individual aspects of immunologically mediated disease.
摘要
先前的研究表明，诸如γ干扰素（IFN-γ）和肿瘤坏死因子-α（TNF-α）等细胞因子对于移植物抗宿主反应（GvHR）的发生至关重要，但这些研究并未确定单个细胞因子是否对该疾病的不同特征负责。在本报告中，我们表明IFN-γ的产生与疾病的早期增殖阶段相关，而晚期的破坏性阶段则与TNF-α的产生相关。这些研究可能有助于开发针对免疫介导疾病各个方面的特异性免疫疗法。
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本文引用的文献
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Int Immunol. 1993 Apr;5(4):399-407. doi: 10.1093/intimm/5.4.399.
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Eur J Immunol. 1993 Feb;23(2):333-7. doi: 10.1002/eji.1830230205.
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