Cherian T, Ponnuraj E, Kuruvilla T, Kirubakaran C, John T J, Raghupathy P
Department of Child Health, Christian Medical College & Hospital, Vellore.
Indian J Med Res. 1994 Aug;100:51-6.
This report describes an epidemic of dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS) in the North Arcot Ambedkar district and the adjoining districts in Tamil Nadu and Andhra Pradesh. Nineteen children who fulfilled the clinical criteria for the diagnosis of DHF/DSS were admitted to the Christian Medical College Hospital, Vellore, during June through November, 1990. The clinical presentation was similar to that described in South-east Asian children and the case fatality rate was 26.3 per cent. Serology was confirmatory or suggestive of recent dengue virus infection in 16 children, uninterpretable in 2 and not consistent with recent dengue virus infection in 1 child. All children over 1 yr of age had very high antibody titres suggesting a secondary response whereas infants had lower titres consistent with primary response. The occurrence of recurrent epidemics in this region in the last few years with associated high case fatality emphasizes the urgent need for public health measures to curtail further epidemics.
本报告描述了北阿尔科特安贝德卡尔区以及泰米尔纳德邦和安得拉邦相邻地区的登革出血热/登革休克综合征（DHF/DSS）疫情。1990年6月至11月期间，19名符合DHF/DSS诊断临床标准的儿童被收治于韦洛尔的基督教医学院医院。临床表现与东南亚儿童的描述相似，病死率为26.3%。血清学检测证实或提示16名儿童近期感染了登革病毒，2名儿童的检测结果无法解读，1名儿童的检测结果与近期登革病毒感染不符。所有1岁以上儿童的抗体滴度都非常高，表明是二次免疫反应，而婴儿的抗体滴度较低，符合初次免疫反应。该地区在过去几年中反复出现疫情，且病死率较高，这凸显了采取公共卫生措施以遏制进一步疫情的迫切需求。
